Proyectos de Investigación / Research  Projects

  • FONDECYT REGULAR 1190341: Mechanism of Congenital Chagas disease: Effective placental Trypanosoma cruzi infection depends on specific host-derived microRNAs

  • ERANet17/HLH-0142: Congenital Chagas Disease Consortium: Identification and validation of biomarkers to improve the control of congenital Chagas disease.

  • FONDECYT POSTDOCTORAL 3190449: Estudio de la actividad tripanocida de cumarinas análogas a resveratrol en diferentes modelos biológicos como inhibidores potenciales de arginina quinasa

  • ERANET-LAC ELAC2014/HID-0328: CONGENITAL CHAGAS DISEASE RESEARCH CONSORTIUM. Argentina, Chile, Bélgica, España.

  • URC-024/16 Red de Química Médica para el desarrollo de nuevos de potenciales agentes quimioterapéuticos antiparasitarios. Programa U-Redes: Línea 2 incentivo a la Consolidación de Red; Domeyko II.

  • ENL027/16 The human placenta: Local molecular and cellular factors that determine the resistance and susceptibility to Trypanosoma cruzi and Toxoplasma gondii infectionFondo Central de Investigación VID Universidad de Chile

  • FONDECYT 1150175 Evaluation and design of a new prototypes of trypanocide drugs derivate of nitroindazole, organometallic complexes and coumarine families. C. Olea / J. Maya; M. Zuñiga; U. KemmerlingUCH / Facultad de Ciencias Químicas y Farmacéuticas, Departamento de Química Inorgánica y Analítica, Departamento de Química Inorgánica y Analítica.

  • FONDEQUIP EQM130042 Plataforma de microscopía confocal para uso en investigaciones biomédicas avanzadas01-12-201301-12-2014L. Leyton / A. Criollo; A. Paula; D. Bravo; E. Jaimovich; G. Diaz; K. Marcelain; M. Behrens; M. Chiong; M. Vega; S. Buvinic; S. Lavandero; U. Kemmerling; V. TorresUCH / Facultad de Medicina, Instituto de Ciencias Biomédicas, Programa de Biología Celular y Molecular. Concurso de Equipamiento Científico.

  • FONDECYT 1130113 DNA repair enzymes and pathways involved in Trypanosoma cruzisurvival to oxidative assault.N. Galanti / G. Cabrera; L. Ferreira; U. KemmerlingUCH / Facultad de Medicina, Instituto de Ciencias Biomédicas, Programa de Biología Celular y Molecular.

  • FONDECYT1130189 Molecular mechanisms of endothelial dysfunction in chronic chagas' heart Disease: a therapeutic approach for the statins. Maya / R. López; U. Kemmerling UCH / Facultad de Medicina, Instituto de Ciencias Biomédicas, Programa de Farmacología Molecular y ClínicaFONDECYTRegular

 

Proyectos pasados / Past Projects

  • FONDECYT REGULAR 1120230: Mechanism of congenital Chagas disease: Effective infection depends on the interplay between T. cruzi and the trophoblast in the human placenta.

  • REDES 130118: Institut Pasteur, Montevideo, Uruguay- Laboratorio mecanismos Infección Parasitaria.

  • Proyecto de Cooperación Científica Internacional CONICYT/MINCYT 2011-595: “Mecanismos de infección de Trypanosoma cruzi en placenta humana: estudios destinados a prevenir la enfermedad de Chagas congénita”

  • Programa Bicentenario de Ciencia y Tecnología, Proyecto Anillo ACT112 “Advanced Center for Traning and Research in the Design of Pharmacological and Immunological Strategies for the Control of Parasitic and Neoplasic Aggressions”.

  • Proyecto Fondecyt N° 11080166 de Iniciación: “Congenital Chagas´ disease: Mechanism of Trypanosoma cruzi infection and invasion in human placenta”. 

Publicaciones / Publications

Liempi A, Castillo C, Medina L, Rojas-Pirela M, Araneda S, Maya JD, Parraguez
VH, Kemmerling U. Ex vivo infection of canine and ovine placental explants with
Trypanosoma cruzi and Toxoplasma gondii: differential activation of NF kappa B
signaling pathways. Acta Trop. 2021 Feb;214:105766. doi:
10.1016/j.actatropica.2020.105766. Epub 2020 Nov 24. PMID: 33245906.

Medina L, Castillo C, Liempi A, Guerrero-Muñoz J, Rojas-Pirela M, Maya JD,
Prieto H, Kemmerling U. <i>Trypanosoma cruzi</i> and <i>Toxoplasma gondii</i>
Induce a Differential MicroRNA Profile in Human Placental Explants. Front
Immunol. 2020 Nov 6;11:595250. doi: 10.3389/fimmu.2020.595250. PMID: 33240284;
PMCID: PMC7677230.

3: Rojas-Pirela M, Andrade-Alviárez D, Rojas V, Kemmerling U, Cáceres AJ,
Michels PA, Concepción JL, Quiñones W. Phosphoglycerate kinase: structural
aspects and functions, with special emphasis on the enzyme from Kinetoplastea.
Open Biol. 2020 Nov;10(11):200302. doi: 10.1098/rsob.200302. Epub 2020 Nov 25.
PMID: 33234025; PMCID: PMC7729029.

Guzmán-Rivera D, Liempi A, González-Herrera F, Fuentes-Retamal S, Carrillo I,
Abarca P, Castillo C, Kemmerling U, Pesce B, Maya JD. Simvastatin Improves
Cardiac Function through Notch 1 Activation in BALB/c Mice with Chronic Chagas
Cardiomyopathy. Antimicrob Agents Chemother. 2020 Jul 22;64(8):e02141-19. doi:
10.1128/AAC.02141-19. PMID: 32393497; PMCID: PMC7526820.

Veas R, Rojas-Pirela M, Castillo C, Olea-Azar C, Moncada M, Ulloa P, Rojas V,
Kemmerling U. Microalgae extracts: Potential anti-Trypanosoma cruzi agents?
Biomed Pharmacother. 2020 Jul;127:110178. doi: 10.1016/j.biopha.2020.110178.
Epub 2020 May 3. PMID: 32371317.

Cipriani M, Rostán S, León I, Li ZH, Gancheff JS, Kemmerling U, Olea Azar C,
Etcheverry S, Docampo R, Gambino D, Otero L. Multi-target heteroleptic palladium
bisphosphonate complexes. J Biol Inorg Chem. 2020 May;25(3):509-519. doi:
10.1007/s00775-020-01779-y. Epub 2020 Mar 30. PMID: 32232584.

Fuentes-Retamal S, Sandoval-Acuña C, Peredo-Silva L, Guzmán-Rivera D, Pavani
M, Torrealba N, Truksa J, Castro-Castillo V, Catalán M, Kemmerling U, Urra FA,
Ferreira J. Complex Mitochondrial Dysfunction Induced by
TPP<sup>+</sup>-Gentisic Acid and Mitochondrial Translation Inhibition by
Doxycycline Evokes Synergistic Lethality in Breast Cancer Cells. Cells. 2020 Feb
11;9(2):407. doi: 10.3390/cells9020407. PMID: 32053908; PMCID: PMC7072465.

Liempi A, Castillo C, Medina L, Galanti N, Maya JD, Parraguez VH, Kemmerling
U. Comparative ex vivo infection with Trypanosoma cruzi and Toxoplasma gondii of
human, canine and ovine placenta: Analysis of tissue damage and infection
efficiency. Parasitol Int. 2020 Jun;76:102065. doi:
10.1016/j.parint.2020.102065. Epub 2020 Jan 27. PMID: 32001348.

Campos-Estrada C, González-Herrera F, Greif G, Carillo I, Guzmán-Rivera D,
Liempi A, Robello C, Kemmerling U, Castillo C, Maya JD. Notch receptor
expression in Trypanosoma cruzi-infected human umbilical vein endothelial cells
treated with benznidazole or simvastatin revealed by microarray analysis. Cell
Biol Int. 2020 May;44(5):1112-1123. doi: 10.1002/cbin.11308. Epub 2020 Jan 22.
PMID: 31943572.

Gallardo M, Kemmerling U, Aguayo F, Bleak TC, Muñoz JP, Calaf GM. Curcumin
rescues breast cells from epithelial‑mesenchymal transition and invasion induced
by anti‑miR‑34a. Int J Oncol. 2020 Feb;56(2):480-493. doi:
10.3892/ijo.2019.4939. Epub 2019 Dec 13. PMID: 31894298; PMCID: PMC6959390.

Kemmerling U, Osuna A, Schijman AG, Truyens C. Congenital Transmission of
<i>Trypanosoma cruzi</i>: A Review About the Interactions Between the Parasite,
the Placenta, the Maternal and the Fetal/Neonatal Immune Responses. Front
Microbiol. 2019 Aug 14;10:1854. doi: 10.3389/fmicb.2019.01854. PMID: 31474955;
PMCID: PMC6702454.

Liempi A, Castillo C, Medina L, Rojas M, Maya JD, Parraguez VH, Kemmerling
U. Ex vivo infection of human placental explants with Trypanosoma cruzi and
Toxoplasma gondii: Differential activation of NF kappa B signaling pathways.
Acta Trop. 2019 Nov;199:105153. doi: 10.1016/j.actatropica.2019.105153. Epub
2019 Aug 27. PMID: 31469971.

Lapier M, Ballesteros-Garrido R, Guzman-Rivera D, González-Herrera F,
Aguilera-Venegas B, Moncada-Basualto M, Ballesteros R, Abarca B, Pesce B,
Kemmerling U, Olea-Azar C, Maya JD. Novel [1,2,3]triazolo[1,5-a]pyridine
derivatives are trypanocidal by sterol biosynthesis pathway alteration. Future
Med Chem. 2019 May;11(10):1137-1155. doi: 10.4155/fmc-2018-0242. PMID: 31280672.

Castillo C, Carrillo I, Libisch G, Juiz N, Schijman A, Robello C, Kemmerling
U. Host-parasite interaction: changes in human placental gene expression induced
by Trypanosoma cruzi. Parasit Vectors. 2018 Aug 24;11(1):479. doi:
10.1186/s13071-018-2988-0. PMID: 30143027; PMCID: PMC6109360.

Medina L, Castillo C, Liempi A, Herbach M, Cabrera G, Valenzuela L, Galanti
N, de Los Angeles Curto M, Schijman AG, Kemmerling U. Differential infectivity
of two Trypanosoma cruzi strains in placental cells and tissue. Acta Trop. 2018
Oct;186:35-40. doi: 10.1016/j.actatropica.2018.07.001. Epub 2018 Jul 6. PMID:
30018029.

Díaz-Viraqué F, Chiribao ML, Trochine A, González-Herrera F, Castillo C,
Liempi A, Kemmerling U, Maya JD, Robello C. Old Yellow Enzyme from
<i>Trypanosoma cruzi</i> Exhibits <i>In Vivo</i> Prostaglandin F<sub>2</sub>α
Synthase Activity and Has a Key Role in Parasite Infection and Drug
Susceptibility. Front Immunol. 2018 Mar 7;9:456. doi: 10.3389/fimmu.2018.00456.
PMID: 29563916; PMCID: PMC5845897.

Rojas DA, Urbina F, Moreira-Ramos S, Castillo C, Kemmerling U, Lapier M,
Maya JD, Solari A, Maldonado E. Endogenous overexpression of an active
phosphorylated form of DNA polymerase β under oxidative stress in Trypanosoma
cruzi. PLoS Negl Trop Dis. 2018 Feb 12;12(2):e0006220. doi:
10.1371/journal.pntd.0006220. PMID: 29432450; PMCID: PMC5825160.

Maya JD, Lapier M, Castillo C, Kemmerling U, Campos-Estrada C, López-Muñoz
R. Chronic Chagas cardiomyopathy: a therapeutic challenge and future strategies.
Emerg Top Life Sci. 2017 Dec 22;1(6):579-584. doi: 10.1042/ETLS20170109. PMID:
33525838.

Kemmerling U, Castillo C, Liempi A, Medina L, Carrillo I, Droguett D, Maya
JD, Galanti N. The immune response against Trypanosoma cruzi in the human
placenta. Emerg Top Life Sci. 2017 Dec 22;1(6):573-577. doi:
10.1042/ETLS20170115. PMID: 33525837.

Castillo C, Muñoz L, Carrillo I, Liempi A, Medina L, Galanti N, Maya JD,
Kemmerling U. Toll-like receptor-2 mediates local innate immune response against
Trypanosoma cruzi in ex vivo infected human placental chorionic villi explants.
Placenta. 2017 Dec;60:40-46. doi: 10.1016/j.placenta.2017.10.005. Epub 2017 Oct
21. PMID: 29208238.

21: Peredo-Silva L, Fuentes-Retamal S, Sandoval-Acuña C, Pavani M, Maya JD,
Castro-Castillo V, Madrid-Rojas M, Rebolledo S, Kemmerling U, Parra E, Ferreira
J. Derivatives of alkyl gallate triphenylphosphonium exhibit antitumor activity
in a syngeneic murine model of mammary adenocarcinoma. Toxicol Appl Pharmacol.
2017 Aug 15;329:334-346. doi: 10.1016/j.taap.2017.06.017. Epub 2017 Jun 21.
PMID: 28647477.

Aplin JD, Beristain A, DaSilva-Arnold S, Dunk C, Duzyj C, Golos TG,
Kemmerling U, Knöfler M, Mitchell MD, Olson DM, Petroff M, Pollheimer J, Reyes
L, Schedin P, Soares MJ, Stencel-Baerenwald J, Thornburg KL, Lash GE. IFPA
meeting 2016 workshop report III: Decidua-trophoblast interactions; trophoblast
implantation and invasion; immunology at the maternal-fetal interface; placental
inflammation. Placenta. 2017 Dec;60 Suppl 1:S15-S19. doi:
10.1016/j.placenta.2017.04.019. Epub 2017 Apr 25. PMID: 28456431.

González-Herrera F, Cramer A, Pimentel P, Castillo C, Liempi A, Kemmerling
U, Machado FS, Maya JD. Erratum for González-Herrera et al., "Simvastatin
Attenuates Endothelial Activation through 15-Epi-Lipoxin A4 Production in Murine
Chronic Chagas Cardiomyopathy". Antimicrob Agents Chemother. 2017 Apr
24;61(5):e00507-17. doi: 10.1128/AAC.00507-17. Erratum for: Antimicrob Agents
Chemother. 2017 Feb 23;61(3): PMID: 28438799; PMCID: PMC5404598.

Castillo C, Muñoz L, Carrillo I, Liempi A, Gallardo C, Galanti N, Maya JD,
Kemmerling U. Ex vivo infection of human placental chorionic villi explants with
Trypanosoma cruzi and Toxoplasma gondii induces different Toll-like receptor
expression and cytokine/chemokine profiles. Am J Reprod Immunol. 2017 Jul;78(1).
doi: 10.1111/aji.12660. Epub 2017 Mar 22. PMID: 28328108.

González-Herrera F, Cramer A, Pimentel P, Castillo C, Liempi A, Kemmerling
U, Machado FS, Maya JD. Simvastatin Attenuates Endothelial Activation through
15-Epi-Lipoxin A4 Production in Murine Chronic Chagas Cardiomyopathy. Antimicrob
Agents Chemother. 2017 Feb 23;61(3):e02137-16. doi: 10.1128/AAC.02137-16.
Erratum in: Antimicrob Agents Chemother. 2017 Apr 24;61(5): PMID: 27993857;
PMCID: PMC5328563.

Droguett D, Carrillo I, Castillo C, Gómez F, Negrete M, Liempi A, Muñoz L,
Galanti N, Maya JD, Kemmerling U. Trypanosoma cruzi induces cellular
proliferation in the trophoblastic cell line BeWo. Exp Parasitol. 2017
Feb;173:9-17. doi: 10.1016/j.exppara.2016.12.005. Epub 2016 Dec 8. PMID:
27939813.

27: Ponce I, Aldunate C, Valenzuela L, Sepúlveda S, Garrido G, Kemmerling U,
Cabrera G, Galanti N. A Flap Endonuclease (TcFEN1) Is Involved in Trypanosoma
cruzi Cell Proliferation, DNA Repair, and Parasite Survival. J Cell Biochem.
2017 Jul;118(7):1722-1732. doi: 10.1002/jcb.25830. Epub 2016 Dec 29. PMID:
27935092.

Seguel V, Castro L, Reigada C, Cortes L, Díaz MV, Miranda MR, Pereira CA,
Lapier M, Campos-Estrada C, Morello A, Kemmerling U, Maya JD, López-Muñoz R.
Pentamidine antagonizes the benznidazole's effect in vitro, and lacks of synergy
in vivo: Implications about the polyamine transport as an anti-Trypanosoma cruzi
target. Exp Parasitol. 2016 Dec;171:23-32. doi: 10.1016/j.exppara.2016.10.007.
Epub 2016 Oct 8. PMID: 27729250.

Díaz-Luján C, Triquell MF, Castillo C, Hardisson D, Kemmerling U, Fretes RE.
Role of placental barrier integrity in infection by Trypanosoma cruzi. Acta
Trop. 2016 Dec;164:360-368. doi: 10.1016/j.actatropica.2016.09.021. Epub 2016
Sep 26. PMID: 27686961.

Liempi A, Castillo C, Carrillo I, Muñoz L, Droguett D, Galanti N, Maya JD,
Kemmerling U. A local innate immune response against Trypanosoma cruzi in the
human placenta: The epithelial turnover of the trophoblast. Microb Pathog. 2016
Oct;99:123-129. doi: 10.1016/j.micpath.2016.08.022. Epub 2016 Aug 21. PMID:
27554274.

Carrillo I, Droguett D, Castillo C, Liempi A, Muñoz L, Maya JD, Galanti N,
Kemmerling U. Caspase-8 activity is part of the BeWo trophoblast cell defense
mechanisms against Trypanosoma cruzi infection. Exp Parasitol. 2016
Sep;168:9-15. doi: 10.1016/j.exppara.2016.06.008. Epub 2016 Jun 18. PMID:
27328973.

Ormeño F, Barrientos C, Ramirez S, Ponce I, Valenzuela L, Sepúlveda S, Bitar
M, Kemmerling U, Machado CR, Cabrera G, Galanti N. Expression and the Peculiar
Enzymatic Behavior of the Trypanosoma cruzi NTH1 DNA Glycosylase. PLoS One. 2016
Jun 10;11(6):e0157270. doi: 10.1371/journal.pone.0157270. PMID: 27284968; PMCID:
PMC4902261.

 

Liempi, A., et al. (2015). "Trypanosoma cruzi infectivity assessment in "in vitro" culture systems by automated cell counting." Acta Tropica 143: 47-50. doi: 10.1016/j.actatropica.2014.12.006.

 

Campos-Estrada, C., et al. (2015). "Simvastatin and Benznidazole-Mediated Prevention of Trypanosoma cruzi-Induced Endothelial Activation: Role of 15-epi-lipoxin A4 in the Action of Simvastatin." Plos Neglected Tropical Diseases 9(5). doi: 10.1371/journal.pntd.0003770.

Diaz-Lujan, C., et al. (2015). "CONGENITAL TRANSMISSION OF PROTOZOA: PLACENTAL INFECTION BY TRYPANOSOMA CRUZI." Placenta 36(4): 480-480.

              

Liempi, A., et al. (2014). "Trypanosoma cruzi induces trophoblast differentiation: A potential local antiparasitic mechanism of the human placenta?" Placenta 35(12): 1035-1042. doi: 10.1016/j.placenta.2014.09.017.

Rojo, G., et al. (2014) "Toxic and therapeutic effects of Nifurtimox and Benznidazol on Trypanosoma cruzi ex vivo infection of human placental chorionic villi explants. Acta TropApr;132:112-8. doi: 10.1016/j.actatropica.2014.01.002."

Jimenez, V., et al. (2014). "Natural sesquiterpene lactones induce programmed cell death in Trypanosoma cruzi: a new therapeutic target? Phytomedicine.Sep 25;21(11):1411-8. doi: 10.1016/j.phymed.2014.06.005.

               

Liempi, A., et al. (2014). "Congenital infection of protozoa: histopathological and histochemical analysis of human chorionic villi explants infected ex vivo with Trypanosoma cruzi and Toxoplasma gondii" Placenta 35(9): A61-A62.

Sepulveda, S., et al. (2014). "Expression, Functionality, and Localization of Apurinic/Apyrimidinic Endonucleases in Replicative and Non-Replicative Forms of Trypanosoma cruzi." Journal of Cellular Biochemistry 115(2): 397-409.

 

Jara, J. A., et al. (2014). "Antiproliferative and Uncoupling Effects of Delocalized, Lipophilic, Cationic Gallic Acid Derivatives on Cancer Cell Lines. Validation in Vivo in Singenic Mice." Journal of Medicinal Chemistry 57(6): 2440-2454.            

Castillo, C., et al. (2013). "The Interaction of Classical Complement Component C1 with Parasite and Host Calreticulin Mediates Trypanosoma cruzi Infection of Human Placenta." Plos Neglected Tropical Diseases 7(8).doi: 10.1371/journal.pntd.0002376.

 

Castillo, C., et al. (2013). "Phospholipase C gamma and ERK1/2 Mitogen Activated Kinase Pathways are differentially modulated by Trypanosoma cruzi during tissue invasion in human placenta." Experimental Parasitology 133(1): 12-17. doi: 10.1016/j.exppara.2012.10.012.

 

Apt, W., et al. (2013). "Congenital infection by Trypanosoma cruzi in an endemic area of Chile: a multidisciplinary study." Transactions of the Royal Society of Tropical Medicine and Hygiene 107(2): 98-104.

Demoro, B., et al. (2013). "Potential Mechanism of the Anti-trypanosomal Activity of Organoruthenium Complexes with Bioactive Thiosemicarbazones." Biological Trace Element Research 153(1-3): 371-381.

Jana, F., et al. (2013). "Tumor cell death induced by the inhibition of mitochondrial electron transport: The effect of 3-hydroxybakuchiol." Toxicology and Applied Pharmacology 272(2): 356-364.

Droguett, D., et al. (2013). "TRYPANOSOMA CRUZI INDUCES CELLULAR PROLIFERATION IN THE TROPHOBLASTIC CELL LINE BEWO." Placenta 34(9): A78-A78.

Molina-Berrios, A., et al. (2013). "Protective Role of Acetylsalicylic Acid in Experimental Trypanosoma cruzi Infection: Evidence of a 15-epi-Lipoxin A(4)-Mediated Effect." Plos Neglected Tropical Diseases 7(4).

Molina-Berrios, A., et al. (2013). "Protection of vascular endothelium by aspirin in a murine model of chronic Chagas' disease." Parasitology Research 112(7): 2731-2739.

Molina-Berrios, A., et al. (2013). "Benznidazole prevents endothelial damage in an experimental model of Chagas disease." Acta Tropica 127(1): 6-13.

Ferreira, A., et al. (2013). "The interaction of classical complement component C1 with parasite and host calreticulin mediates Trypanosoma cruzi infection of human placenta." Journal of Immunology 190.

Aguilera-Venegas, B., et al. (2012). "Electrochemical, ESR and Theoretical Insights into the Free Radical Generation by 1,1 '-Hydrocarbylenebisindazoles and Its Evaluation as Potential Bio-Active Compounds." International Journal of Electrochemical Science 7(7): 5837-5863.               

Ramirez, G., et al. (2012). "Roles of Trypanosoma cruzi calreticulin in parasite-host interactions and in tumor growth." Molecular Immunology 52(3-4): 133-140.

          

Castillo, C., et al. (2012). "Role of matrix metalloproteinases 2 and 9 in ex vivo Trypanosoma cruzi infection of human placental chorionic villi." Placenta 33(12): 991-997. doi: 10.1016/j.placenta.2012.10.004.

Fretes, R.. amd Kemmerling U. (2012).Congenital transmission by protozoan.J Trop Med2012:173437. doi: 10.1155/2012/173437.

               

Duaso, J., et al. (2011). "Trypanosoma cruzi induces apoptosis in ex vivo infected human chorionic villi." Placenta 32(5): 356-361.

Al-Khan, A., et al. (2011). "IFPA Meeting 2010 Workshops Report II: Placental pathology; Trophoblast invasion; Fetal sex; Parasites and the placenta; Decidua and embryonic or fetal loss; Trophoblast differentiation and syncytialisation." Placenta 32: S90-S99.

Aguilera-Venegas, B., et al. (2011). "ESR, electrochemical, molecular modeling and biological evaluation of 4-substituted and 1,4-disubstituted 7-nitroquinoxalin-2-ones as potential anti-Trypanosoma cruzi agents." Spectrochimica Acta Part a-Molecular and Biomolecular Spectroscopy 78(3): 1004-1012.

Cabrera, G., et al. (2011). "DNA Repair BER Pathway Inhibition Increases Cell Death Caused by Oxidative DNA Damage in Trypanosoma cruzi." Journal of Cellular Biochemistry 112(8): 2189-2199.

Rivera, C. A., et al. (2011). "Chronic Restraint Stress in Oral Squamous Cell Carcinoma." Journal of Dental Research 90(6): 799-803.

               

Duaso, J., et al. (2010). "Trypanosoma cruzi induces tissue disorganization and destruction of chorionic villi in an ex vivo infection model of human placenta." Placenta 31(8): 705-711.               

               

Kemmerling, U., et al. (2010). "Infection and invasion mechanisms of Trypanosoma cruzi in the congenital transmission of Chagas' disease: A proposal." Biological Research 43(3): 307-316.

               

Duaso, J., et al. (2010). "TRYPANOSOMA CRUZI INDUCES APOPTOSIS IN HUMAN CHORIONIC VILLI EXPLANTS." Placenta 31(9): A114-A114.

Cabrera, G., et al. (2010). "Mesocestoides corti: Morphological features and glycogen mobilization during in vitro differentiation from larva to adult worm." Parasitology 137(3): 373-384.

               

Maya, JD., et al. (2010). "Chagas disease: Present status of pathogenic mechanisms and chemotherapy." Biological Research 43(3): 323-331.

               

Lopez-Munoz, R., et al. (2010). "Trypanosoma cruzi: In vitro effect of aspirin with nifurtimox and benznidazole." Experimental Parasitology 124(2): 167-171.

               

Vieites, M., et al. (2009). "Platinum-based complexes of bioactive 3-(5-nitrofuryl)acroleine thiosemicarbazones showing anti-Trypanosoma cruzi activity." Journal of Inorganic Biochemistry 103(3): 411-418.     

Rodriguez, J., et al. (2009). "Study of 5-nitroindazoles' anti-Trypanosoma cruzi mode of action: Electrochemical behaviour and ESR spectroscopic studies." European Journal of Medicinal Chemistry 44(4): 1545-1553.             

Faundez, M., et al. (2008). "Buthionine sulfoximine has anti-Trypanosoma cruzi activity in a murine model of acute Chagas' disease and enhances the efficacy of nifurtimox." Antimicrobial Agents and Chemotherapy 52(5): 1837-1839.         

Salas, C., et al. (2008). "Trypanosoma cruzi: Activities of lapachol and alpha- and beta-lapachone derivatives against epimastigote and trypomastigote forms." Bioorganic & Medicinal Chemistry 16(2): 668-674.

 

Kemmerling, U., et al. (2006). "Localization, specific activity, and molecular forms of acetylcholinesterase in developmental stages of the cestode Mesocestoides corti." Journal of Cellular Physiology 206(2): 503-509.      

               

Carrsaco, M. A., et al. (2005). "Calcium release mediated by redox activation of ryanodine receptors induces CREB and ERK phosphorylation in N2a cells and hippocampal neurons." Febs Journal 272: 421-421.

Lopez-Solis, R. O. and U. Kemmerling (2005). "Codominant expression of genes coding for different sets of inducible salivary polypeptides associated with parotid hypertrophy in two inbred mouse strains." Journal of Cellular Biochemistry 95(1): 99-107.