Proyectos en curso / Current Projects

  • ERANET-LAC ELAC2014/HID-0328: CONGENITAL CHAGAS DISEASE RESEARCH CONSORTIUM. Argentina, Chile, Bélgica, España.

  • URC-024/16 Red de Química Médica para el desarrollo de nuevos de potenciales agentes quimioterapéuticos antiparasitarios. Programa U-Redes: Línea 2 incentivo a la Consolidación de Red; Domeyko II.

  • ENL027/16 The human placenta: Local molecular and cellular factors that determine the resistance and susceptibility to Trypanosoma cruzi and Toxoplasma gondii infectionFondo Central de Investigación VID Universidad de Chile

  • FONDECYT 1150175 Evaluation and design of a new prototypes of trypanocide drugs derivate of nitroindazole, organometallic complexes and coumarine families. C. Olea / J. Maya; M. Zuñiga; U. KemmerlingUCH / Facultad de Ciencias Químicas y Farmacéuticas, Departamento de Química Inorgánica y Analítica, Departamento de Química Inorgánica y Analítica.

  • FONDEQUIP EQM130042 Plataforma de microscopía confocal para uso en investigaciones biomédicas avanzadas01-12-201301-12-2014L. Leyton / A. Criollo; A. Paula; D. Bravo; E. Jaimovich; G. Diaz; K. Marcelain; M. Behrens; M. Chiong; M. Vega; S. Buvinic; S. Lavandero; U. Kemmerling; V. TorresUCH / Facultad de Medicina, Instituto de Ciencias Biomédicas, Programa de Biología Celular y Molecular. Concurso de Equipamiento Científico.

  • FONDECYT 1130113 DNA repair enzymes and pathways involved in Trypanosoma cruzisurvival to oxidative assault.N. Galanti / G. Cabrera; L. Ferreira; U. KemmerlingUCH / Facultad de Medicina, Instituto de Ciencias Biomédicas, Programa de Biología Celular y Molecular.

  • FONDECYT1130189 Molecular mechanisms of endothelial dysfunction in chronic chagas' heart Disease: a therapeutic approach for the statins. Maya / R. López; U. Kemmerling UCH / Facultad de Medicina, Instituto de Ciencias Biomédicas, Programa de Farmacología Molecular y ClínicaFONDECYTRegular

 

Proyectos pasados / Past Projects

  • FONDECYT REGULAR 1120230: Mechanism of congenital Chagas disease: Effective infection depends on the interplay between T. cruzi and the trophoblast in the human placenta.

  • REDES 130118: Institut Pasteur, Montevideo, Uruguay- Laboratorio mecanismos Infección Parasitaria.

  • Proyecto de Cooperación Científica Internacional CONICYT/MINCYT 2011-595: “Mecanismos de infección de Trypanosoma cruzi en placenta humana: estudios destinados a prevenir la enfermedad de Chagas congénita”

  • Programa Bicentenario de Ciencia y Tecnología, Proyecto Anillo ACT112 “Advanced Center for Traning and Research in the Design of Pharmacological and Immunological Strategies for the Control of Parasitic and Neoplasic Aggressions”.

  • Proyecto Fondecyt N° 11080166 de Iniciación: “Congenital Chagas´ disease: Mechanism of Trypanosoma cruzi infection and invasion in human placenta”. 

Publicaciones / Publications

González-Herrera F. et al. (2016). "Simvastatin attenuates endothelial activation through 15-epi-lipoxin A4 production in murine chronic Chagas cardiomyopathy. Antimicrob Agents Chemother. Dec 19. pii: AAC.02137-16."

Droguett, D., et al. (2016). " Trypanosoma cruzi induces cellular proliferation in the trophoblastic cell line BeWo.Exp Parasitol. Dec 8;173:9-17. doi: 10.1016/j.exppara.2016.12.005."

Ponce, I., et al. (2016). "A Flap Endonuclease (TcFEN1) Is Involved in Trypanosoma cruzi Cell Proliferation, DNA Repair, and Parasite Survival. J Cell Biochem.Dec 9. doi: 10.1002/jcb.25830."

 

Ormeño, F. et al.,(2016). " Expression and the Peculiar Enzymatic Behavior of the Trypanosoma cruzi NTH1 DNA Glycosylase.PLoS One. Jun 10;11(6):e0157270. doi: 10.1371/journal.pone.0157270"

Liempi, A., er al. (2016). "A local innate immune response against Trypanosoma cruzi in the human placenta: The epithelial turnover of the trophoblast. Microb Pathog.Oct;99:123-129. doi: 10.1016/j.micpath.2016.08.022. Review."

Carrillo, I., et al. (2016). "Caspase-8 activity is part of the BeWo trophoblast cell defense mechanisms against Trypanosoma cruzi infection. Exp Parasitol. Sep;168:9-15. doi: 10.1016/j.exppara.2016.06.008."

Seguel V., et al, (2016}. "Pentamidine antagonizes the benznidazole's effect in vitro, and lacks of synergy in vivo: Implications about the polyamine transport as an anti-Trypanosoma cruzi target". Exp Parasitol. Dec;171:23-32. doi: 10.1016/j.exppara.2016.10.007.

Díaz-Luján C., et al, (2016) . "Role of placental barrier integrity in infection by Trypanosoma cruzi". Dec;164:360-368. doi: 10.1016/j.actatropica.2016.09.021..

 

Liempi, A., et al. (2015). "Trypanosoma cruzi infectivity assessment in "in vitro" culture systems by automated cell counting." Acta Tropica 143: 47-50. doi: 10.1016/j.actatropica.2014.12.006.

 

Campos-Estrada, C., et al. (2015). "Simvastatin and Benznidazole-Mediated Prevention of Trypanosoma cruzi-Induced Endothelial Activation: Role of 15-epi-lipoxin A4 in the Action of Simvastatin." Plos Neglected Tropical Diseases 9(5). doi: 10.1371/journal.pntd.0003770.

Diaz-Lujan, C., et al. (2015). "CONGENITAL TRANSMISSION OF PROTOZOA: PLACENTAL INFECTION BY TRYPANOSOMA CRUZI." Placenta 36(4): 480-480.

              

Liempi, A., et al. (2014). "Trypanosoma cruzi induces trophoblast differentiation: A potential local antiparasitic mechanism of the human placenta?" Placenta 35(12): 1035-1042. doi: 10.1016/j.placenta.2014.09.017.

Rojo, G., et al. (2014) "Toxic and therapeutic effects of Nifurtimox and Benznidazol on Trypanosoma cruzi ex vivo infection of human placental chorionic villi explants. Acta TropApr;132:112-8. doi: 10.1016/j.actatropica.2014.01.002."

Jimenez, V., et al. (2014). "Natural sesquiterpene lactones induce programmed cell death in Trypanosoma cruzi: a new therapeutic target? Phytomedicine.Sep 25;21(11):1411-8. doi: 10.1016/j.phymed.2014.06.005.

               

Liempi, A., et al. (2014). "Congenital infection of protozoa: histopathological and histochemical analysis of human chorionic villi explants infected ex vivo with Trypanosoma cruzi and Toxoplasma gondii" Placenta 35(9): A61-A62.

Sepulveda, S., et al. (2014). "Expression, Functionality, and Localization of Apurinic/Apyrimidinic Endonucleases in Replicative and Non-Replicative Forms of Trypanosoma cruzi." Journal of Cellular Biochemistry 115(2): 397-409.

 

Jara, J. A., et al. (2014). "Antiproliferative and Uncoupling Effects of Delocalized, Lipophilic, Cationic Gallic Acid Derivatives on Cancer Cell Lines. Validation in Vivo in Singenic Mice." Journal of Medicinal Chemistry 57(6): 2440-2454.            

Castillo, C., et al. (2013). "The Interaction of Classical Complement Component C1 with Parasite and Host Calreticulin Mediates Trypanosoma cruzi Infection of Human Placenta." Plos Neglected Tropical Diseases 7(8).doi: 10.1371/journal.pntd.0002376.

 

Castillo, C., et al. (2013). "Phospholipase C gamma and ERK1/2 Mitogen Activated Kinase Pathways are differentially modulated by Trypanosoma cruzi during tissue invasion in human placenta." Experimental Parasitology 133(1): 12-17. doi: 10.1016/j.exppara.2012.10.012.

 

Apt, W., et al. (2013). "Congenital infection by Trypanosoma cruzi in an endemic area of Chile: a multidisciplinary study." Transactions of the Royal Society of Tropical Medicine and Hygiene 107(2): 98-104.

Demoro, B., et al. (2013). "Potential Mechanism of the Anti-trypanosomal Activity of Organoruthenium Complexes with Bioactive Thiosemicarbazones." Biological Trace Element Research 153(1-3): 371-381.

Jana, F., et al. (2013). "Tumor cell death induced by the inhibition of mitochondrial electron transport: The effect of 3-hydroxybakuchiol." Toxicology and Applied Pharmacology 272(2): 356-364.

Droguett, D., et al. (2013). "TRYPANOSOMA CRUZI INDUCES CELLULAR PROLIFERATION IN THE TROPHOBLASTIC CELL LINE BEWO." Placenta 34(9): A78-A78.

Molina-Berrios, A., et al. (2013). "Protective Role of Acetylsalicylic Acid in Experimental Trypanosoma cruzi Infection: Evidence of a 15-epi-Lipoxin A(4)-Mediated Effect." Plos Neglected Tropical Diseases 7(4).

Molina-Berrios, A., et al. (2013). "Protection of vascular endothelium by aspirin in a murine model of chronic Chagas' disease." Parasitology Research 112(7): 2731-2739.

Molina-Berrios, A., et al. (2013). "Benznidazole prevents endothelial damage in an experimental model of Chagas disease." Acta Tropica 127(1): 6-13.

Ferreira, A., et al. (2013). "The interaction of classical complement component C1 with parasite and host calreticulin mediates Trypanosoma cruzi infection of human placenta." Journal of Immunology 190.

Aguilera-Venegas, B., et al. (2012). "Electrochemical, ESR and Theoretical Insights into the Free Radical Generation by 1,1 '-Hydrocarbylenebisindazoles and Its Evaluation as Potential Bio-Active Compounds." International Journal of Electrochemical Science 7(7): 5837-5863.               

Ramirez, G., et al. (2012). "Roles of Trypanosoma cruzi calreticulin in parasite-host interactions and in tumor growth." Molecular Immunology 52(3-4): 133-140.

          

Castillo, C., et al. (2012). "Role of matrix metalloproteinases 2 and 9 in ex vivo Trypanosoma cruzi infection of human placental chorionic villi." Placenta 33(12): 991-997. doi: 10.1016/j.placenta.2012.10.004.

Fretes, R.. amd Kemmerling U. (2012).Congenital transmission by protozoan.J Trop Med2012:173437. doi: 10.1155/2012/173437.

               

Duaso, J., et al. (2011). "Trypanosoma cruzi induces apoptosis in ex vivo infected human chorionic villi." Placenta 32(5): 356-361.

Al-Khan, A., et al. (2011). "IFPA Meeting 2010 Workshops Report II: Placental pathology; Trophoblast invasion; Fetal sex; Parasites and the placenta; Decidua and embryonic or fetal loss; Trophoblast differentiation and syncytialisation." Placenta 32: S90-S99.

Aguilera-Venegas, B., et al. (2011). "ESR, electrochemical, molecular modeling and biological evaluation of 4-substituted and 1,4-disubstituted 7-nitroquinoxalin-2-ones as potential anti-Trypanosoma cruzi agents." Spectrochimica Acta Part a-Molecular and Biomolecular Spectroscopy 78(3): 1004-1012.

Cabrera, G., et al. (2011). "DNA Repair BER Pathway Inhibition Increases Cell Death Caused by Oxidative DNA Damage in Trypanosoma cruzi." Journal of Cellular Biochemistry 112(8): 2189-2199.

Rivera, C. A., et al. (2011). "Chronic Restraint Stress in Oral Squamous Cell Carcinoma." Journal of Dental Research 90(6): 799-803.

               

Duaso, J., et al. (2010). "Trypanosoma cruzi induces tissue disorganization and destruction of chorionic villi in an ex vivo infection model of human placenta." Placenta 31(8): 705-711.               

               

Kemmerling, U., et al. (2010). "Infection and invasion mechanisms of Trypanosoma cruzi in the congenital transmission of Chagas' disease: A proposal." Biological Research 43(3): 307-316.

               

Duaso, J., et al. (2010). "TRYPANOSOMA CRUZI INDUCES APOPTOSIS IN HUMAN CHORIONIC VILLI EXPLANTS." Placenta 31(9): A114-A114.

Cabrera, G., et al. (2010). "Mesocestoides corti: Morphological features and glycogen mobilization during in vitro differentiation from larva to adult worm." Parasitology 137(3): 373-384.

               

Maya, JD., et al. (2010). "Chagas disease: Present status of pathogenic mechanisms and chemotherapy." Biological Research 43(3): 323-331.

               

Lopez-Munoz, R., et al. (2010). "Trypanosoma cruzi: In vitro effect of aspirin with nifurtimox and benznidazole." Experimental Parasitology 124(2): 167-171.

               

Vieites, M., et al. (2009). "Platinum-based complexes of bioactive 3-(5-nitrofuryl)acroleine thiosemicarbazones showing anti-Trypanosoma cruzi activity." Journal of Inorganic Biochemistry 103(3): 411-418.     

Rodriguez, J., et al. (2009). "Study of 5-nitroindazoles' anti-Trypanosoma cruzi mode of action: Electrochemical behaviour and ESR spectroscopic studies." European Journal of Medicinal Chemistry 44(4): 1545-1553.             

Faundez, M., et al. (2008). "Buthionine sulfoximine has anti-Trypanosoma cruzi activity in a murine model of acute Chagas' disease and enhances the efficacy of nifurtimox." Antimicrobial Agents and Chemotherapy 52(5): 1837-1839.         

Salas, C., et al. (2008). "Trypanosoma cruzi: Activities of lapachol and alpha- and beta-lapachone derivatives against epimastigote and trypomastigote forms." Bioorganic & Medicinal Chemistry 16(2): 668-674.

 

Kemmerling, U., et al. (2006). "Localization, specific activity, and molecular forms of acetylcholinesterase in developmental stages of the cestode Mesocestoides corti." Journal of Cellular Physiology 206(2): 503-509.      

               

Carrsaco, M. A., et al. (2005). "Calcium release mediated by redox activation of ryanodine receptors induces CREB and ERK phosphorylation in N2a cells and hippocampal neurons." Febs Journal 272: 421-421.

Lopez-Solis, R. O. and U. Kemmerling (2005). "Codominant expression of genes coding for different sets of inducible salivary polypeptides associated with parotid hypertrophy in two inbred mouse strains." Journal of Cellular Biochemistry 95(1): 99-107.

               

               

               

               

               

               

               

 

 

               

               

               

               

               

               

               

               

               

               

               

               

               

               

               

               

               

               

               

               

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